Anti-TGF beta antibody[STJ95997]
Product nameAnti-TGF beta antibodyShort DescriptionRabbit polyclonal against TGF betaDescriptionTGF-beta 1 is a protein encod
Product nameAnti-TGF beta antibodyShort DescriptionRabbit polyclonal against TGF betaDescriptionTGF-beta 1 is a protein encod
| Product name | Anti-TGF beta antibody[STJ95997] |
|---|---|
| Short Description | Rabbit polyclonal against TGF beta |
| Description | TGF-beta 1 is a protein encoded by the TGFB1 gene which is approximately 44,3 kDa. TGF-beta 1 is secreted into the extracellular space and matrix and is involved in apoptotic pathways in synovial fibroblasts, SMAD2/3 MH2 domain mutants in cancer, Th17 differentiation pathway, GPCR pathway and ERK signalling. This protein falls under the TGF-beta superfamily which bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. It is a multifunctional protein that controls proliferation, differentiation and other functions in many cell types. TGF-beta 1 is highly expressed in bone. Mutations in the TGFB1 gene may result in Camurati-Engelmann disease and Cystic Fibrosis, Renal Fibrosis. STJ95997 was developed from clone 5D2. It was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This mouse monoclonal antibody detects endogenous levels of TGF-beta 1. |
| Applications | ELISA, IF, IHC, WB |
| Dilution range | WB 1:500-1:2000 IHC 1:100-1:300 IF 1:200-1:1000 ELISA 1:20000 |
| Specificity | TGFbeta1 Polyclonal Antibody detects endogenous levels of TGFbeta1 protein. |
| Protein Name | Transforming growth factor beta-1 TGF-beta-1 Latency-associated peptide LAP |
| Immunogen | Synthesized peptide derived from human TGFbeta1 |
| Immunogen Region | 310-390 aa, C-terminal |
| Storage Instruction | Store at -20°C, and avoid repeat freeze-thaw cycles. |
| Note | For Research Use Only (RUO). |
| Validated Application |    |
| Host | Rabbit |
|---|---|
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Conjugation | Unconjugated |
| Concentration | 1 mg/ml |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Isotype | IgG |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene ID | 7040 |
|---|---|
| Gene Symbol | TGFB1 |
| Molecular Weight | 44 kDa |
| Database Links | HGNC:11766 OMIM:131300 |
| Alternative Names | Transforming growth factor beta-1 TGF-beta-1 Latency-associated peptide LAP |
| Swiss-Prot Key | P01137_HUMAN |
](/uploads/ueditor/20200825/1-200R5152U5328.png "Anti-TGF beta antibody[STJ95997](图4)")
