Anti-CD4 antibody[STJ180057]
Product nameAnti-CD4 antibodyShort DescriptionRabbit monoclonal against CD4DescriptionCD4, a single chain transmembrane glyco
Product nameAnti-CD4 antibodyShort DescriptionRabbit monoclonal against CD4DescriptionCD4, a single chain transmembrane glyco
| Product name | Anti-CD4 antibody[STJ180057] |
|---|---|
| Short Description | Rabbit monoclonal against CD4 |
| Description | CD4, a single chain transmembrane glycoprotein, is found on a T cell subset (helper/inducer) representing 45% of peripheral blood lymphocytes. It is also present on 80% of thymocytes and at a lower level on monocytes. It is involved in recognition of antigen presented along with MHC class II by APCs. It serves as receptor for HIV. |
| Applications | IHC |
| Dilution range | 1:50-100 |
| Protein Name | T-cell surface glycoprotein CD4 T-cell surface antigen T4/Leu-3 CD antigen CD4 |
| Immunogen | A synthetic peptide corresponding to residues of human CD4 protein |
| Storage Instruction | Store at 2-8°C for up to 1 year |
| Note | For Research Use Only (RUO). |
| Validated Application |  |
| Host | Rabbit |
|---|---|
| Clonality | Monoclonal |
| Reactivity | Human |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Formulation | Purified antibody in 0.2% BSA and 15mM sodium azide. |
| Gene ID | 920 |
|---|---|
| Gene Symbol | CD4 |
| Molecular Weight | 51 kDa |
| Database Links | HGNC:1678 OMIM:186940 Reactome:R-HSA-1462054 |
| Alternative Names | T-cell surface glycoprotein CD4 T-cell surface antigen T4/Leu-3 CD antigen CD4 |
| Function | Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses, In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex, The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins, Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs), In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex, LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells, In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway, Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages, |
| Post-translational Modifications | Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts. |
| Cellular Localization | Cell membrane |
| Tissue Specificity | Highly expressed in T-helper cells. The presence of CD4 is a hallmark of T-helper cells which are specialized in the activation and growth of cytotoxic T-cells, regulation of B cells, or activation of phagocytes. CD4 is also present in other immune cells such as macrophages, dendritic cells or NK cells. |
| Swiss-Prot Key | P01730 |
](/uploads/ueditor/20200825/1-200R5155035a2.png "Anti-CD4 antibody[STJ180057](图2)")
