Anti-2019-nCoV S1 antibody[STJ61040]
Product nameAnti-2019-nCoV S1 antibodyShort DescriptionAnti-2019-nCoV S1 mAb is a human monoclonal antibody human IgG1 and is
Product name | Anti-2019-nCoV S1 antibody[STJ61040] |
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Short Description | Anti-2019-nCoV S1 mAb is a human monoclonal antibody human IgG1 and is produced in mammalian expression system. |
Description | Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation, apoptosis, cancer development and progression, and the innate immune response. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, CEACAM etc.. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. |
Applications | ELISA, WB |
Specificity | This antibody recognizes 2019-nCoV S1 Protein/ 2019-nCoV S-RBD Protein. |
Storage Instruction | Store at -20°C. Stable for 6 months. Minimize freeze-thaw cycles. |
Note | FOR RESEARCH USE ONLY |
Host | Human |
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Clonality | Monoclonal |
Clone ID | 5D9 |
Reactivity | Human |
Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH 7.4. |
Molecular Weight | Mol Mass: 48.9 & 24.2kDa, Apparent Mol Mass: 58&28kDa, reducing conditions. |
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