Anti-Na+/K+-ATPase Alpha antibody[STJ99661]
This antibody detects endogenous levels of Na+/K+-ATPase Œ1.
This antibody detects endogenous levels of Na+/K+-ATPase Œ1.
| Product name | Anti-Na+/K+-ATPase Alpha antibody |
|---|---|
| Short Description | Rabbit polyclonal against Na+/K+-ATPase alpha |
| Description | Rabbit polyclonal to Na+/K+-ATPase alpha1. |
| Applications | ELISA, WB |
| Dilution range | WB 1:500-2000 ELISA 1:10000-20000 |
| Specificity | This antibody detects endogenous levels of Na+/K+-ATPase α1. |
| Protein Name | Sodium/Potassium-Transporting Atpase Subunit Alpha-1 Na(+/K(+ Atpase Alpha-1 Subunit Sodium Pump Subunit Alpha-1 |
| Immunogen | Synthesized peptide derived from human Na+/K+-ATPase alpha1. |
| Storage Instruction | Store at-20°C, and avoid repeat freeze-thaw cycles. |
| Note | FOR RESEARCH USE ONLY (RUO). |
| Host | Rabbit |
|---|---|
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Conjugation | Unconjugated |
| Concentration | 1 mg/ml |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Isotype | IgG |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene ID | 476 |
|---|---|
| Gene Symbol | ATP1A1 |
| Molecular Weight | 130 kDa |
| Database Links | HGNC:799 OMIM:182310 |
| Alternative Names | Anti-Sodium/Potassium-Transporting Atpase Subunit Alpha-1 antibody Anti-Na(+/K(+ Atpase Alpha-1 Subunit antibody Anti-Sodium Pump Subunit Alpha-1 antibody Anti-ATP1A1 antibody |
| Function | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. |
| Post-translational Modifications | Phosphorylation on Tyr-10 modulates pumping activity. Phosphorylation of Ser-943 by PKA modulates the response of ATP1A1 to PKC. Dephosphorylation by protein phosphatase 2A (PP2A) following increases in intracellular sodium, leading to increase catalytic activity. |
| Cellular Localization | Cell Membrane Sarcolemma Multi-Pass Membrane Protein Melanosome Identified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv |
| Swiss-Prot Key | AT1A1_HUMAN |
](https://www.fulaibio.com/uploads/ueditor/20200928/1-20092Q34934234.png "Anti-Na+/K+-ATPase Alpha antibody[STJ99661](图1)")
