Anti-N-cadherin antibody[STJ98267]
Product nameAnti-N-cadherin antibodyShort DescriptionMouse monoclonal against N-cadherinDescriptionMouse monoclonal to N-cadh
Product nameAnti-N-cadherin antibodyShort DescriptionMouse monoclonal against N-cadherinDescriptionMouse monoclonal to N-cadh
| Product name | Anti-N-cadherin antibody |
|---|---|
| Short Description | Mouse monoclonal against N-cadherin |
| Description | Mouse monoclonal to N-cadherin. |
| Applications | ELISA, FC, IF, IHC, WB |
| Dilution range | WB 1:500-1:2000 IHC 1:200-1:1000 IF 1:200-1:1000 FC 1:200-1:400 ELISA 1:10000 |
| Specificity | N-cadherin Monoclonal Antibody detects endogenous levels of N-cadherin protein. |
| Protein Name | Cadherin-2 CDw325 Neural cadherin N-cadherin CD antigen CD325 |
| Immunogen | Purified recombinant fragment of human N-cadherin expressed in E. Coli. |
| Storage Instruction | Store at -20°C, and avoid repeat freeze-thaw cycles. |
| Note | For Research Use Only (RUO). |
| Validated Application | ](https://www.stjohnslabs.com/media/application_icon/FC.png "Anti-N-cadherin antibody[STJ98267](图1)"){kind=icon} ](https://www.stjohnslabs.com/media/application_icon/IF.png "Anti-N-cadherin antibody[STJ98267](图2)"){kind=icon} ](https://www.stjohnslabs.com/media/application_icon/IHC.png "Anti-N-cadherin antibody[STJ98267](图3)"){kind=icon} ](https://www.stjohnslabs.com/media/application_icon/WB.png "Anti-N-cadherin antibody[STJ98267](图4)"){kind=icon} |
| Host | Mouse |
|---|---|
| Clonality | Monoclonal |
| Clone ID | 5D5 |
| Reactivity | Human, Mouse, Rat |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Isotype | IgGMale |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
| Gene ID | 1000 |
|---|---|
| Gene Symbol | CDH2 |
| Database Links | HGNC:1759 OMIM:114020 |
| Alternative Names | Cadherin-2 CDw325 Neural cadherin N-cadherin CD antigen CD325 |
| Function | Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density . |
| Post-translational Modifications | Cleaved by MMP24. Ectodomain cleavage leads to the generation of a soluble 90 kDa amino-terminal soluble fragment and a 45 kDa membrane-bound carboxy-terminal fragment 1 (CTF1), which is further cleaved by gamma-secretase into a 35 kDa. Cleavage in neural stem cells by MMP24 affects CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate neural stem cell quiescence . May be phosphorylated by OBSCN. |
| Cellular Localization | Cell membrane Cell membrane, sarcolemma Cell junction Cell surface. Colocalizes with TMEM65 at the intercalated disk in cardiomyocytes. Colocalizes with OBSCN at the intercalated disk and at sarcolemma in cardiomyocytes. |
| Swiss-Prot Key | P19022_HUMAN |
](/uploads/ueditor/20200817/1-200QG23043536.png "Anti-N-cadherin antibody[STJ98267](图5)")
