Product nameAnti-Cleaved-Caspase-7 (S199)

Product name	Anti-Cleaved-Caspase-7 (S199) antibody
Short Description	Rabbit polyclonal against Cleaved-Caspase-7 (S199)
Description	Rabbit polyclonal to Cleaved-Caspase-7 (S199).
Applications	ELISA, IHC, WB
Dilution range	WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:40000
Specificity	Cleaved-Caspase-7 (S199) Polyclonal Antibody detects endogenous levels of fragment of activated Caspase-7 protein resulting from cleavage adjacent to S199.
Protein Name	Caspase-7 CASP-7 Apoptotic protease Mch-3 CMH-1 ICE-like apoptotic protease 3 ICE-LAP3 Caspase-7 subunit p20 Caspase-7 subunit p11
Immunogen	Synthesized peptide derived from human Caspase-7
Immunogen Region	150-230 aa, Internal
Storage Instruction	Store at -20°C, and avoid repeat freeze-thaw cycles.
Note	For Research Use Only (RUO).
Validated Application

Host	Rabbit
Clonality	Polyclonal
Reactivity	Human, Mouse
Conjugation	Unconjugated
Concentration	1 mg/ml
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype	IgG
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Gene ID	840
Gene Symbol	CASP7
Molecular Weight	20 kDa
Database Links	HGNC:1508 OMIM:601761
Alternative Names	Caspase-7 CASP-7 Apoptotic protease Mch-3 CMH-1 ICE-like apoptotic protease 3 ICE-LAP3 Caspase-7 subunit p20 Caspase-7 subunit p11
Function	Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Overexpression promotes programmed cell death.
Post-translational Modifications	Cleavages by granzyme B or caspase-10 generate the two active subunits. Propeptide domains can also be cleaved efficiently by caspase-3. Active heterodimers between the small subunit of caspase-7 and the large subunit of caspase-3, and vice versa, also occur.
Cellular Localization	Cytoplasm.
Tissue Specificity	Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. No expression in the brain.
Swiss-Prot Key	P55210_HUMAN