Anti-PCNA Antibody[STJ72848]
Product nameAnti-PCNA AntibodyShort DescriptionGoat polyclonal against PCNAApplicationsELISA, WBProtein NameProliferating cel
Product nameAnti-PCNA AntibodyShort DescriptionGoat polyclonal against PCNAApplicationsELISA, WBProtein NameProliferating cel
| Product name | Anti-PCNA Antibody[STJ72848] |
|---|---|
| Short Description | Goat polyclonal against PCNA |
| Applications | ELISA, WB |
| Protein Name | Proliferating cell nuclear antigen PCCyclin |
| Immunogen | internal region |
| Storage Instruction | Store at -20°C, and avoid repeat freeze-thaw cycles. |
| Note | For Research Use Only (RUO). |
| Validated Application |   |
| Host | Goat |
|---|---|
| Clonality | Polyclonal |
| Reactivity | Bovine, Canine, Human, Mouse, Rat, Swine |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/ml |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Isotype | IgG |
| Formulation | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Gene ID | 5111 |
|---|---|
| Gene Symbol | PCNA |
| Molecular Weight | 28.8 kDa |
| Database Links | HGNC:8729 OMIM:176740 Reactome:R-HSA-110312 |
| Alternative Names | Proliferating cell nuclear antigen PCCyclin |
| Function | Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand, Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities, Has to be loaded onto DNA in order to be able to stimulate APEX2, Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion, |
| Post-translational Modifications | Phosphorylated, Phosphorylation at Tyr-211 by EGFR stabilizes chromatin-associated PCNA, |
| Cellular Localization | Nucleus, |
| Swiss-Prot Key | P12004 |
| Sequence | NGNIKLSQTSNVD |
](/uploads/ueditor/20200825/1-200R5155K2524.png "Anti-PCNA Antibody[STJ72848](图4)")
