19946275258/13482164108
![Anti-COX4 antibody[STJ97368]](/uploads/allimg/20200928/1-20092Q359124R.jpg)
![Anti-COX4 antibody[STJ97368]](/uploads/allimg/20200928/1-20092Q35ZSP.jpg)
| Product name | Anti-COX4 antibody |
|---|---|
| Short Description | Rabbit polyclonal against COX4 |
| Description | Rabbit polyclonal to COX4. |
| Applications | IHC-p, WB |
| Dilution range | WB 1:1000 IHC 1:500-1000 |
| Specificity | The antibody detects endogenous COX4 protein. |
| Protein Name | Cytochrome C Oxidase Subunit 4 Isoform 1-Mitochondrial Cytochrome C Oxidase Polypeptide Iv Cytochrome C Oxidase Subunit Iv Isoform 1 Cox Iv-1 |
| Immunogen | Recombinant Protein |
| Storage Instruction | Store at-20°C, and avoid repeat freeze-thaw cycles. |
| Note | FOR RESEARCH USE ONLY (RUO). |
| Host | Rabbit |
|---|---|
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Conjugation | Unconjugated |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Isotype | IgG |
| Formulation | PBS, pH 7.4, containing 0.5% BSA, 0.02% sodium azide and 50% Glycerol. |
| Gene ID | 1327 |
|---|---|
| Gene Symbol | COX4I1 |
| Database Links | HGNC:2265 OMIM:123864 |
| Alternative Names | Anti-Cytochrome C Oxidase Subunit 4 Isoform 1-Mitochondrial antibody Anti-Cytochrome C Oxidase Polypeptide Iv antibody Anti-Cytochrome C Oxidase Subunit Iv Isoform 1 antibody Anti-Cox Iv-1 antibody Anti-COX4I1 COX4 antibody |
| Function | Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunbit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. |
| Cellular Localization | Mitochondrion Inner Membrane Single-Pass Membrane Protein |
![Anti-COX4 antibody[STJ97368]](/uploads/thumb/350_350/1-20092Q35Z0A5.jpeg)
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