19946275258/15301726783
![Anti-Bax antibody[STJ97729]](/uploads/allimg/20200924/1-200924110419550.jpg)
![Anti-Bax antibody[STJ97729]](/uploads/allimg/20200924/1-2009241104195c.jpg)
| Product name | Anti-Bax antibodySTJ97729] |
|---|---|
| Short Description | Mouse monoclonal against Bax |
| Description | Mouse monoclonal to Bax. |
| Applications | IHC-p, WB |
| Dilution range | WB 1:1000-2000 IHC 1:100-200 |
| Specificity | Bax protein detects endogenous levels of BAX |
| Protein Name | Apoptosis Regulator Bax Bcl-2-Like Protein 4 Bcl2-L-4 |
| Immunogen | synthetic peptide derived from Bax |
| Immunogen Region | 30-110 aa |
| Storage Instruction | Store at-20°C, and avoid repeat freeze-thaw cycles. |
| Note | FOR RESEARCH USE ONLY (RUO). |
| Host | Mouse |
|---|---|
| Clonality | Monoclonal |
| Clone ID | 1C1 |
| Reactivity | Human, Mouse, Rat |
| Conjugation | Unconjugated |
| Concentration | 1 mg/ml |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Isotype | IgG1 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene ID | 581 |
|---|---|
| Gene Symbol | BAX |
| Database Links | HGNC:959 OMIM:600040 |
| Alternative Names | Anti-Apoptosis Regulator Bax antibody Anti-Bcl-2-Like Protein 4 antibody Anti-Bcl2-L-4 antibody Anti-BAX BCL2L4 antibody |
| Function | Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. |
| Cellular Localization | Isoform Alpha: Mitochondrion Outer Membrane Single-Pass Membrane Protein Cytoplasm Colocalizes With 14-3-3 Proteins In The Cytoplasm Under Stress Conditions Undergoes A Conformation Change That Causes Release From Jnk-Phosphorylated 14-3-3 Proteins And Translocation To The Mitochondrion Membrane Isoform Beta: Cytoplasm Isoform Gamma: Cytoplasm Isoform Delta: Cytoplasm |
| Tissue Specificity | Expressed in a wide variety of tissues. Isoform Psi is found in glial tumors. Isoform Alpha is expressed in spleen, breast, ovary, testis, colon and brain, and at low levels in skin and lung. Isoform Sigma is expressed in spleen, breast, ovary, testis, lung, colon, brain and at low levels in skin. Isoform Alpha and isoform Sigma are expressed in pro-myelocytic leukemia, histiocytic lymphoma, Burkitt's lymphoma, T-cell lymphoma, lymphoblastic leukemia, breast adenocarcinoma, ovary adenocarcinoma, prostate c |
| Swiss-Prot Key | BAX_HUMAN |
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