19946275258/15301726783
![Anti-IL-6 antibody[STJ96713]](/uploads/allimg/20200916/1-2009161A4403O.jpg)
![Anti-IL-6 antibody[STJ96713]](/uploads/allimg/20200916/1-2009161A4403V.jpg)
![Anti-IL-6 antibody[STJ96713]](/uploads/allimg/20200916/1-2009161A4405T.jpg)
| Product name | Anti-IL-6 antibody[STJ96713] |
|---|---|
| Short Description | Rabbit polyclonal against IL-6 |
| Description | IL-6 is a protein encoded by the IL6 gene which is approximately 23, 7 kDa. IL-6 is secreted and is involved in apoptotic pathways in synovial fibroblasts, PEDF induced signalling, the GPCR Pathway, the TGF-Beta pathway and toll-like receptor signalling pathways. IL6 is a cytokine that functions in inflammation and the maturation of B cells. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor. IL-6 is expressed in the lung, blood, nervous system, bone marrow and the intestines. Mutations in the IL6 gene result in rheumatoid arthritis systemic juvenile and an inflammatory articular disorder. STJ96713 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of IL-6 protein. |
| Applications | ELISA, IHC-p, WB |
| Dilution range | WB 1:500-1:2000 IHC-p 1:100-1:300 ELISA 1:20000 |
| Specificity | IL-6 polyclonal antibody detects endogenous levels of IL-6 protein. |
| Protein Name | Interleukin-6 Il-6 B-Cell Stimulatory Factor 2 Bsf-2 Ctl Differentiation Factor Cdf Hybridoma Growth Factor Interferon Beta-2 Ifn-Beta-2 |
| Immunogen | Synthesized peptide derived from human IL-6. |
| Immunogen Region | Internal |
| Storage Instruction | Store at-20°C, and avoid repeat freeze-thaw cycles. |
| Note | FOR RESEARCH USE ONLY (RUO). |
| Host | Rabbit |
|---|---|
| Clonality | Polyclonal |
| Reactivity | Human |
| Conjugation | Unconjugated |
| Concentration | 1 mg/ml |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Isotype | IgG |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene ID | 3569 |
|---|---|
| Gene Symbol | IL6 |
| Molecular Weight | 25 kDa |
| Database Links | HGNC:6018 OMIM:147620 |
| Alternative Names | Anti-Interleukin-6 antibody Anti-Il-6 antibody Anti-B-Cell Stimulatory Factor 2 antibody Anti-Bsf-2 antibody Anti-Ctl Differentiation Factor antibody Anti-Cdf antibody Anti-Hybridoma Growth Factor antibody Anti-Interferon Beta-2 antibody Anti-Ifn-Beta-2 antibody Anti-IL6 IFNB2 antibody |
| Function | Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation. |
| Post-translational Modifications | N-and O-glycosylated. |
| Cellular Localization | Secreted |
| Swiss-Prot Key | IL6_HUMAN |
](/uploads/ueditor/20200911/1-2009111219141N.png "Anti-IL-6 antibody[STJ96713](图1)")
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