19946275258/15301726783
![Anti-PD-L1 antibody[STJ130023]](/uploads/allimg/20200916/1-200916163140217.jpg)
![Anti-PD-L1 antibody[STJ130023]](/uploads/allimg/20200916/1-200916163140V2.jpg)
![Anti-PD-L1 antibody[STJ130023]](/uploads/allimg/20200916/1-200916163134218.jpg)
| Product name | Anti-PD-L1 antibody[STJ130023] |
|---|---|
| Short Description | Rabbit monoclonal against PD-L1 |
| Description | Programmed death-ligand 1 (PD-L1) is a 40kDa type 1 transmembrane protein that suppresses immune system. PD-L1 is expressed in hematopoietic and nonhematopoietic cells including T cells and B cells and various types of tumor cells. PD-L1 binds to its receptor Programmed death 1 (PD1). During infection or inflammation, PD1PD-L1 interaction is important for preventing autoimmunity. In tumor microenvironments, PD1-PD-L1 interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human cancers. In recent years, PDL1 has become an important biomarker and immunotherapy target for many types of malignancies. |
| Applications | WB |
| Specificity | human PD-L1 |
| Protein Name | Programmed death-ligand 1 |
| Immunogen | Recombinant human PD-L1 extracellular domain |
| Storage Instruction | Store Anti-PD-L1 Antibody at -20°C, and avoid repeated freeze-thaw cycles. |
| Note | For Research Use Only (RUO) |
| Validated Application |    |
| Host | Rabbit |
|---|---|
| Clonality | Monoclonal |
| Clone ID | 8C6 |
| Reactivity | |
| Conjugation | Unconjugated |
| Purification | Protein A agarose affinity chromatography of tissue culture supernatant |
| Isotype | |
| Formulation | PBS with 0.09% sodium azide, and 50% glycerol at pH7.4 |
| Gene ID | 29126 |
|---|---|
| Gene Symbol | CD274 |
| Molecular Weight | 34 kDa |
| Database Links | HGNC:17635 OMIM:605402 |
| Alternative Names | Programmed death-ligand 1 |
| Function | Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production. {ECO:0000269|PubMed:10581077, ECO:0000269|PubMed:11015443}. |
| Cellular Localization | Isoform 1: Cell membrane {ECO:0000269|PubMed:15780196}. Single-pass type I membrane protein {ECO:0000255}.. Isoform 2: Endomembrane system {ECO:0000269|PubMed:15780196}. Single-pass type I membrane protein {ECO:0000255}. |
| Tissue Specificity | Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes. {ECO:0000269|PubMed:10581077, ECO:0000269|PubMed:11015443}. |
| Swiss-Prot Key | Q9NZQ7_HUMAN |
](/uploads/ueditor/20200903/1-200Z3104J0645.png "Anti-PD-L1 antibody[STJ130023](图4)")
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