19946275258/15301726783
![Anti-HPK1 antibody[STJ93590]](/uploads/allimg/20200901/1-200Z110154aV.jpg)
![Anti-HPK1 antibody[STJ93590]](/uploads/allimg/20200901/1-200Z1101320440.jpg)
| Product name | Anti-HPK1 antibody |
|---|---|
| Short Description | Rabbit polyclonal against HPK1 |
| Description | HPK1 is a protein encoded by the MAP4K1 gene which is approximately 91, 3 kDa. HPK1 is localised to the cytoplasm and cell membrane. It is involved in the TGF-beta pathway, MAPK signalling pathway, B cell receptor signalling pathway and NF-kappa B signalling. It is a serine/threonine-protein kinase, which may play a role in the response to environmental stress. It appears to act upstream of the JUN N-terminal pathway and may also play a role in hematopoietic lineage decisions and growth regulation. HPK1 is expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Mutations in the MAP4K1 gene may result in Paget disease. STJ93590 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of HPK1 protein. |
| Applications | ELISA, IHC-p, WB |
| Dilution range | WB 1:500-1:2000 ELISA 1:10000 |
| Specificity | HPK1 polyclonal antibody detects endogenous levels of HPK1 protein. |
| Protein Name | Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1 Hematopoietic Progenitor Kinase Mapk/Erk Kinase Kinase Kinase 1 Mek Kinase Kinase 1 Mekkk 1 |
| Immunogen | Synthesized peptide derived from human HPK1 |
| Immunogen Region | 340-420 aa, Internal |
| Storage Instruction | Store at-20°C, and avoid repeat freeze-thaw cycles. |
| Note | FOR RESEARCH USE ONLY (RUO). |
| Host | Rabbit |
|---|---|
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Conjugation | Unconjugated |
| Concentration | 1 mg/ml |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Isotype | IgG |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene ID | 11184 |
|---|---|
| Gene Symbol | MAP4K1 |
| Molecular Weight | 91 kDa |
| Database Links | HGNC:6863 OMIM:601983 |
| Alternative Names | Anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1 antibody Anti-Hematopoietic Progenitor Kinase antibody Anti-Mapk/Erk Kinase Kinase Kinase 1 antibody Anti-Mek Kinase Kinase 1 antibody Anti-Mekkk 1 antibody Anti-MAP4K1 HPK1 antibody |
| Function | Serine/threonine-protein kinase, which may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation. Able to autophosphorylate. Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production. |
| Post-translational Modifications | Autophosphorylates: phosphorylation promotes ubiquitination by the Cul7-RING(FBXW8) ubiquitin-protein ligase complex, leading to its degradation by the proteasome.; Tyrosine-phosphorylated after activation of hemopoietic cells.; Ubiquitinated by the Cul7-RING(FBXW8) ubiquitin-protein ligase complex following autophosphorylation, leading to its degradation by the proteasome. |
| Tissue Specificity | Expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Also expressed at very low levels in lung, kidney, mammary glands and small intestine. |
| Swiss-Prot Key | M4K1_HUMAN |
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