19946275258/15301726783
![Anti-MAP2 antibody[STJ120119]](/uploads/allimg/20200722/1-200H21G23RC.gif)
![Anti-MAP2 antibody[STJ120119]](/uploads/allimg/20200722/1-200H21G242B8.gif)
| Product name | Anti-MAP2 antibody【STJ120119】 |
|---|---|
| Description | Microtubules are 25nm diameter protein rods found in most kinds of eukaryotic cells. They are polymerized from a dimeric subunit made of one a subunit and one b tubulin subunit. Microtubules are associated with a family of proteins called microtubule associated proteins (MAPs), which includes the protein τ (tau) and a group of proteins referred to as MAP1, MAP2, MAP3, MAP4 and MAP5 (Kindler & Gardner 1994). MAP2 is made up of two ~280 kDa apparent molecular weight bands referred to as MAP2a and MAP2b. A third lower molecular weight form, usually called MAP2c, corresponds to a pair of protein bands running at ~70 kDa on SDS-PAGE gels. All these MAP2 forms are derived from a single gene by alternate transcription, and all share a C-terminal sequence which includes either three or four microtubule binding peptide Western blot of rat cortical lysate showing specific immunolabeling of the ~280 kDa MAP2 protein. sequences, which are very similar to those found in the related microtubule binding protein τ (tau). MAP2 isoforms are expressed only in neuronal cells and specifically in the perikarya and dendrites of these cells. MAP2 has been recently shown to be the specific receptor for the neurosteroid pregnenolone (Fontaine-Lenore V. et al., 2006). |
| Applications | IF, WB |
| Dilution range | WB 1:20000; IF 1:2500 |
| Protein Name | Microtubule-Associated Protein 2 Map-2 |
| Immunogen | recombinant bovine MAP2 protein expressed in and purification from E. Coli. |
| Storage Instruction | Store at-20°C, and avoid repeated freeze-thaw cycles. |
| Note | FOR RESEARCH USE ONLY (RUO). |
| Host | Chicken |
|---|---|
| Clonality | Polyclonal |
| Reactivity | Bovine, Human, Mouse, Rat |
| Conjugation | Unconjugated |
| Purification | This antibody was total igy fraction. |
| Formulation | Total IgY fraction in PBS + 10 mM NaN3. |
| Gene ID | 4133 |
|---|---|
| Molecular Weight | 280 kDa |
| Database Links | HGNC:6839 OMIM:157130 |
| Alternative Names | Anti-Microtubule-Associated Protein 2 antibody Anti-Map-2 antibody Anti-MAP2 antibody |
| Function | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
| Post-translational Modifications | Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly. Isoform 2 is probably phosphorylated by PKA at Ser-323, Ser-354 and Ser-386 and by FYN at Tyr-67. The interaction with KNDC1 enhances MAP2 threonine phosphorylation. |
| Cellular Localization | Cytoplasm Cytoskeleton Cell Projection Dendrite |
| Swiss-Prot Key | MTAP2_HUMAN |
](/uploads/ueditor/20200817/1-200QG30923123.png "Anti-MAP2 antibody[STJ120119](图1)")
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