19946275258/15301726783
![Anti-VGF antibody[STJ96661]](/uploads/allimg/20200709/1-200F9154TTN.jpg)
![Anti-VGF antibody[STJ96661]](/uploads/allimg/20200709/1-200F9155T4225.jpg)
![Anti-VGF antibody[STJ96661]](/uploads/allimg/20200709/1-200F9155T1256.jpg)
| Product name | Anti-VGF antibody[STJ96661] |
|---|---|
| Short Description | Rabbit polyclonal against VGF |
| Description | VGF is a protein encoded by the VGF gene which is approximately 67, 2 kDa. VGF is secreted and is involved in growth factor activity and neuropeptide hormone activity. VGF is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. It may be involved in the regulation of cell-cell interactions or in synatogenesis during the maturation of the nervous system. VGF is expressed in the central and peripheral nervous systems, it is synthesized exclusively in neuronal and neuroendocrine cells. Mutations in the VGF gene may result in pulmonary large cell Neuroendocrine Carcinoma and Pheochromocytoma. STJ96661 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of VGF protein. |
| Applications | ELISA, IHC-p, WB |
| Dilution range | WB 1:500-1:2000 IHC-p 1:100-1:300 ELISA 1:20000 |
| Specificity | VGF polyclonal antibody detects endogenous levels of VGF protein. |
| Protein Name | Neurosecretory Protein Vgf [Cleaved Into-Neuroendocrine Regulatory Peptide-1 Nerp-1-Neuroendocrine Regulatory Peptide-2 Nerp-2-Vgf-Derived Peptide Tlqp-21-Vgf-Derived Peptide Tlqp-62-Antimicrobial Peptide Vgf[554-577]] |
| Immunogen | Synthesized peptide derived from human VGF. |
| Immunogen Region | 441-490 aa, Internal |
| Storage Instruction | Store at-20°C, and avoid repeat freeze-thaw cycles. |
| Note | FOR RESEARCH USE ONLY (RUO). |
| Host | Rabbit |
|---|---|
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Conjugation | Unconjugated |
| Concentration | 1 mg/ml |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Isotype | IgG |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide |
| Gene ID | 7425 |
|---|---|
| Gene Symbol | VGF |
| Molecular Weight | 67 kDa |
| Database Links | HGNC:12684 OMIM:602186 |
| Alternative Names | Anti-Neurosecretory Protein Vgf [Cleaved Into-Neuroendocrine Regulatory Peptide-1 antibody Anti-Nerp-1-Neuroendocrine Regulatory Peptide-2 antibody Anti-Nerp-2-Vgf-Derived Peptide Tlqp-21-Vgf-Derived Peptide Tlqp-62-Antimicrobial Peptide Vgf[554-577]] antibody Anti-VGF antibody |
| Function | [Neurosecretory protein VGF]: Secreted polyprotein that is packaged and proteolytically processed by prohormone convertases PCSK1 and PCSK2 in a cell-type-specific manner. VGF and peptides derived from its processing play many roles in neurogenesis and neuroplasticity associated with learning, memory, depression and chronic pain. [Neuroendocrine regulatory peptide-1]: Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Suppresses presynaptic glutamatergic neurons connected to vasopressin neurons. [Neuroendocrine regulatory peptide-2]: Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Activates GABAergic interneurons which are inhibitory neurons of the nervous system and thereby suppresses presynaptic glutamatergic neurons. Stimulates also feeding behavior in an orexin-dependent manner in the hypothalamus. Functions as a positive regulator for the activation of orexin neurons resulting in elevated gastric acid secretion and gastric emptying. [VGF-derived peptide TLQP-21]: Secreted multifunctional neuropeptide that binds to different cell receptors and thereby plays multiple physiological roles including modulation of energy expenditure, pain, response to stress, gastric regulation, glucose homeostasis as well as lipolysis. Activates the G-protein-coupled receptor C3AR1 via a folding-upon-binding mechanism leading to enhanced lipolysis in adipocytes. Interacts with C1QBP receptor in macrophages and microglia causing increased levels of intracellular calcium and hypersensitivity. [VGF-derived peptide TLQP-62]: Plays a role in the regulation of memory formation and depression-related behaviors potentially by influencing synaptic plasticity and neurogenesis. Induces acute and transient activation of the NTRK2/TRKB receptor and subsequent CREB phosphorylation. Induces also insulin secretion in insulinoma cells by increasing intracellular calcium mobilization. [Antimicrobial peptide VGF[554-577]]: Has bactericidal activity against M. luteus, and antifungal activity against P. Pastoris. |
| Post-translational Modifications | Multiple peptides are derived from VGF, with activities in synaptic plasticity, antidepression, penile erection, autonomic activation, and increases in energy expenditure. |
| Cellular Localization | Neurosecretory Protein Vgf: Secreted Cytoplasmic Vesicle Secretory Vesicle Stored In Secretory Vesicles And Then Secreted Nerp Peptides Colocalize With Vasopressin In The Storage Granules Of Hypothalamus |
| Tissue Specificity | Central and peripheral nervous systems, synthesized exclusively in neuronal and neuroendocrine cells. |
| Swiss-Prot Key |
](/uploads/ueditor/20200817/1-200QG32540G1.png "Anti-VGF antibody[STJ96661](图1)")
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